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Problems with fetal growth Physical defects in the offspring Higher rates of embryo and fetal deaths These issues seem tied to reduced calorie intake and slower stomach emptying, which are usual effects of GLP-1 drugs
In a 48-week phase II clinical trial conducted on patients with type 2 diabetes and obesity, treatment with a dose of 10 mg/kg of bimagrumab resulted in a significant reduction in fat mass by 20.5% (compared to 0.5% in the placebo group), while lean body mass increased by 3.6% (as opposed to a decrease of 0.8% in the placebo group), leading to an overall body weight reduction of -6.5%, which was substantially better than the -0.8% observed in the placebo group
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A daily multivitamin and mineral supplement is commonly recommended when overall food intake drops substantially, to help meet requirements for nutrients such as iron, vitamin B12, calcium, and vitamin D
Across these applications, GHKCu functions as a research reagent for dissecting biochemical and cellular pathways
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