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The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle
Hsp90, in particular, serves to stabilize client proteins, including calcineurin, important for tolerating azole, echinocandin, and polyene fungicidal activity
It also stimulates focal adhesion kinase (FAK)-paxillin complexes, which help cells migrate and attach during tissue reconstruction
Oxidative stress has been implicated as a driver of blinding eye diseases and a broad spectrum of serious chronic conditions
The same free thiol (-SH) group that enables thiol exchange also allows NAC to act as a direct, localized antioxidant
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