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If dose reduction is considered due to side effects, the FDA-approved alternative maintenance dose of 1.7 mg weekly may be appropriate
Conversely, upregulation of FTL1 and ferritin heavy chain (FTH1), or inhibition of NCOA4, can suppress ferroptosis ( in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis
The per-component split and the full reconstitution math follow
The figure displays the chemical structures of vitamin C, semihydroascorbic acid, and dehydroascorbic acid
doi: 10.1155/2018/3295807 153 LeeJSKimJLeeEJYoonJS
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