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Clinical perspective The ASCO 2026 data is genuinely interesting, but it should not change the clinical question
Ipamorelin is a synthetic pentapeptide GH secretagogue (Aib-His-D-2-Nal-D-Phe-Lys-NH) and selective GHS-R1a (ghrelin receptor) agonist, distinguished within the GHRP class by its exceptional selectivity for GH release with minimal co-stimulation of cortisol, prolactin, or ACTH
No head-to-head comparison has evaluated once-daily versus twice-daily regimens
For most patients, optimizing semaglutide or tirzepatide dosing produces results comparable to or better than experimental combinations
Full details of comparison analyses are provided in Supplementary Information
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