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To date, two mammalian Grxs have been characterized, with Grx1 being mostly cytosolic and Grx2 found primarily in mitochondria
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Production requires a considerable metabolic input from ATP, methyl groups, and specific nutrients, including B vitamins, selenium, and amino acids
There is also a high degree of heterogeneity among participants of the analyzed studies
Biochem Biophys Res Commun, 1999
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