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Multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance
PMID: 19238460 Prescription Information: rxlist.com (cocaine / topical) rxlist.com (Goprelto ) topical cocaine nasal spray Keywords Imipramine Trade Name: Tofranil Drug Class: TCA antidepressant (tricyclic amine) Mechanism of Action: Blocks presynaptic reuptake transporters for norepinephrine & serotonin (NET & SERT) on nerve endings (therapeutic effects) Antimuscarinic (contributes to side effects) Antihistamine (contributes to side effects) Alpha receptor blocking properties (contributes to side effects) Several weeks to months are required for antidepressant effects to appear (or be significantly greater than a placebo), although its direct effects (e.g
10.1016/j.bbagen.2014.12.001 Biochim Biophys Acta
doi: 10.1016/j.nmd.2025.105369 26
Adding complextity to BBB-microglia interaction, a study by Krasnow et al., revealed that murine brain microvascular endothelial cells exposed to IL-1 before co-cultured with microglia, amplifies inflammatory gene expression in microglia, as compared to IL-1 exposure of isolated microglia (Krasnow et al., 2017)
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