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Semaglutide is not usually considered safe to use during pregnancy , and official prescribing information says to stop it when pregnancy is recognized and to stop it at least 2 months before a planned pregnancy
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However, due to the scarcity and high price of NBC, in recent years, Bovis Calculus Artifactus (BCA), Bovis Calculus Sativus (BCS), cultured Bovis Calculus (CBC), and other substitutes for NBC have been successfully developed to address urgent clinical needs (Yang et al., 1996)
This was surprising given that GLP-1 agonists do increase heart rate slightly in clinical settings
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