glp 1 controversy Sex Differences in the Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists for Weight Reduction: A Systematic Review and Meta‐Analysis - Yang - 2025 - Journal of Diabetes Use of GLP - 1

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doi: 10.1056/NEJMoa2403347 12 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al

Once mutant and/or misfolded proteins with a loss- or gain-of-function or damaged and potentially harmful cellular structures cannot be effectively eliminated, cells undergo malignant transformation, which may progress to carcinogenesis (Edinger and Thompson, 2003)

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While losing some lean mass during aggressive weight loss is expected, this ratio is favorable compared to diet-only approaches where lean mass losses can reach 30-40%