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three participants in the IcoSema group and two participants in the semaglutide group discontinued treatment owing to gastrointestinal AEs

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[8] [9] GLP-1 medications work through several complementary mechanisms: Enhancing insulin secretion from pancreatic beta cells in response to elevated blood glucose Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , helping you feel fuller for longer Acting on appetite centres in the brain to reduce hunger and food intake In the UK, commonly prescribed GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), lixisenatide (Lyxumia) and exenatide (Byetta, Bydureon)

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