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Eur J Pharmacol 781:8391 Staresinic M, Petrovic I, Novinscak T, Jukic I, Pevec D, Suknaic S, Kokic N, Batelja L, Brcic L, Boban-Blagaic A (2006) Effective therapy of transected quadriceps muscle in rat: gastric pentadecapeptide BPC 157

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The absence of receptor downregulation or tolerance development in research suggests sustained effectiveness without the need for dose escalation over time