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) 188 (Wiley-Blackwell, 2016)
PIONEER 6 was an event-driven CVOT that used time from randomization to first occurrence of a MACE as the primary outcome
Food and Drug Administration, Website, Accessed June 2025 Cancer Research UK, Website, Accessed June 2025 Federal Register, Website, Accessed June 2025 Dermatology and Dermatitis , May 2024, pages 1-4 Medical and Clinical Research , September 2024, pages 1-8 International Journal of Oral and Maxillofacial Surgery , April 2025, ePublication
Contraindications listed include medullary thyroid carcinoma, MEN 2, and certain diabetic retinopathy complications
242-246 In one placebo-controlled trial that included 60 participants with anxiety and depression, 50 mg saffron daily for 12 weeks reduced scores on tests assessing anxiety and depression symptoms
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