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Specifically, while nanoemulsified CUR resulted in a 4-fold increase in Caspase 3 levels-a key marker of apoptosis-the combination treatment involving nanoemulsified PPR led to a 6-fold elevation of this marker

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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

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