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Phase 2 Trial Data, What Researchers Are Working From The pivotal Phase 2 trial (Jastreboff et al., NEJM 2023, NCT04881760) enrolled 338 adults across six cohorts over 48 weeks

The table above only illustrates how the math works for two example concentrations

These changes, though not classically classified as AEs, can have important implications for metabolic health and physical function, and their magnitude appears to vary depending on factors such as baseline nutritional status, physical activity, and adherence to dietary interventions

This represents hard endpoint data showing actual reductions in heart attacks, strokes, and cardiovascular deaths