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Data availability This narrative review is based on published sources

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According to the American Liver Foundation, MASH is a progressive liver condition that affects about 5 percent of US adults

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Mechanistic studies show that ACTL6A upregulates GCLC as a cotranscription factor with Nuclear factor (erythroid-derived 2)-like 2 (NRF2) and that the hydrophobic region of ACTL6A plays an important role

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Trends in Endocrinology & Metabolism

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