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The degree of melanin pigmentation is determined by the number and distribution of melanocytes in the basal cell layer of the oral epithelium of each anatomical region, by their melanogenic activity, by the degree of arborisation of the dendritic processes of the melanocytes, and by the number, size, and distribution of melanosomes in the melanocyte-keratinocyte unit [46]

developed a nano-carrier based on a PAMAM-G4 core modified with L-serine (S-G-R NPs) for loading the natural antioxidant rosmarinic acid (RA), achieving dual enhancement of its antioxidant efficacy and in vivo utilization

Additionally, it has been proven to lower blood sugar levels, which is crucial for those managing diabetes

10.1186/s12933-016-0468-4 9

In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females