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These molecules target enzymes that break down proteins, which is particularly relevant in conditions where excessive protein degradation contributes to disease pathology

Clinical trials The first dual IDO1 and TDO2 inhibitor Phase I clinical trial (NCT03306420) was completed with 15 enrolled patients with advanced solid tumors ( Figure 3 ) ( Figure 3 While the final results from the ACTRN trial are still pending, findings from the NCT trial suggest that dual inhibition of IDO1 and TDO2 may enhance the effectiveness of immunotherapies by reversing the immunosuppressive environment created by the KP

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