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10.1042/0264-6021:3610417 Biochem

269 In a subsequent randomised placebo-controlled trial ( n = 63) of the same probiotic at a dose of 5 billion CFU for 12 weeks, the intervention did not reduce migraine, failing to support the previous open-label study

Alfhili MA, Alsughayyir J

Giving a vitamin B12 supplement to a healthy dog who is eating a nutritionally complete and balanced dog food is usually not necessary, but its also unlikely to be dangerous