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Further, the accumulation of AGEs in the extracellular matrix increases the activity of metalloproteinases and therefore reduces collagen and elastin synthesis [25]

If the cause is irreversible then parental therapy should be continued for life

Endocrinology 156 , 42264237 (2015)

5-Sulfosalicylic acid is recommended for the removal of proteins from sample solutions and for the prevention of GSH oxidation and -glutamyl transpeptidase reactions