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A comprehensive metabolomics and transcriptomics study investigating bioenergetics, including brain and plasma acylcarnitines, in 16 months old APOE3-TR and APOE4-TR mice found increases in FAO in E4s especially in females (Shang et al., 2020)

Stop and seek care for severe abdominal pain

GLP-1 was initially discovered for its ability to enhance glucose-stimulated insulin secretion (GSIS) (Kreymann et al., 1987

It works in a targeted way by selectively binding to ghrelin receptors, stimulating the pituitary gland without raising stress hormones like cortisol or prolactin too much

Its released by specialised cells in the small intestine and plays a central role in regulating blood sugar and appetite