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In SUSTAIN-6 there was non-inferiority for MACE, a composite of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke, with semaglutide (Figure 1, Box 2)
Some patients also find that resting for 15-20 minutes after meals, rather than exercising immediately, reduces stomach upset
Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)
So the results are promising at least when it comes to animals with gut issues
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