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There have been isolated case reports of severe toxicity, almost exclusively in situations of extreme overdose or accidental ingestion by small children

10.1038/oby.2005.117 10 CannevaF.GolubY.DistlerJ.DobnerJ.MeyerS.von HrstenS

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Consuming a meal rich in carbohydrates before drinking may help manage glucose levels, but always consult a healthcare provider for medical advice