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semaglutide generally needs no dose adjustment Patients with kidney disease : Generally no dose adjustments needed for either medication, but monitoring is advised People with diabetes : Should be aware of the risk of diabetic retinopathy progression with rapid improvement in blood glucose control

Pregnancy outcomes after semaglutide exposure

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For new or worsening nephropathy, subcutaneous semaglutide did not significantly reduce the risk (RR 0.83, 95% CI 0.61 to 1.12), but it had a borderline significance compared with placebo (RR 0.81, 95% CI 0.66 to 1.00)