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13 No RCTs have primarily tested the effects of GLP-1 RAs on HF hard outcomes and/or mortality in patients with HFpEF or HF with reduced ejection fraction (HFrEF)

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Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response

This was accompanied by a considerable reduction of body fat mass and, particularly in the case of triagonist-treated mice, a substantial lowering of lean mass (Fig

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