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GLP-1 receptor agonists enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which normally raises blood sugar), and slow gastric emptying
Table of Contents Understanding Nausea with GLP-1 Receptor Agonists GLP-1 receptor agonists cause nausea primarily by slowing gastric emptying, an effect that is most pronounced during treatment initiation and dose escalation
10.1385/nmm:1:1:1 Neuromol
One practical consideration: higher-concentration solutions (2000mcg/mL or above) increase the risk of peptide aggregation during long-term storage, so unless your protocol specifically requires minimal injection volumes, a 1000mcg/mL concentration is the safer choice for multi-week studies
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