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Tissue effects (angiogenesis, VEGF-receptor signaling, growth factor cross-talk) persist much longer than the plasma window
Weeks 16 through 24 and beyond: maintenance phase If the combination has been well-tolerated through the titration phase, maintenance involves continuing both compounds at their established doses while reducing bloodwork frequency to monthly
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We used a simple method based on the incorporation of PI for red fluorescence staining that does not require an extensive knowledge of schistosome biology [40]
Ongoing and Future Research Directions Current research directions focus on mechanistic understanding of BPC-157's cellular and molecular effects
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