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Dietary Gaps and Plant-Based Lifestyles The most common and straightforward reason for low B12 is diet

Flavonoids and isoflavones have minimal inhibitory effects on aromatase and 17-hydroxysteroid dehydrogenases (17-HSD) in breast cancer cells, and they also hinder the generation of active oestrogens & steroid synthesis within cancer cells (128)

Others may identify limitations

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First, the evidence is limited to draw a definitive conclusion: only four small or moderate sized RCTs were included, and the risk of bias is generally moderate