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Astrocytes, positioned at the interface between the brain parenchyma and the perivascular space, which includes capillaries, larger arteries, and veins [66], play a role in the removal of A from the brain via mechanisms that include enzymatic degradation of A and the upregulation of efflux transporters for A at the BBB [67]
Nonetheless, the present study does not directly identify the chemical modification, the modified residues/bonds, or the structural mechanism, all of which await further study
6 Ferroptosis 6.1 Ferroptotic signaling pathway Ferroptosis is an RCD form characterized by iron dependency and lipid peroxide accumulation (186, 187)
Diarrhea May occur especially during dose adjustments
R.ZlokovicB
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