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Through systematic fractionation of human albumin, Pickart and colleagues isolated a small peptide responsible for the difference, eventually identifying it as a three-amino-acid sequence glycine, histidine, and lysine with an unusually strong affinity for binding copper(II) ions

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These findings indicate that the peptide may influence receptor availability or receptor associated signaling complexes in experimental systems [4]

Pre-blends are simpler to handle but lock the ratio between the two compounds