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Ann N Y Acad Sci 1363:99115

Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress-related AMPK/FoxO1 signaling

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When muscles beneath the skin maintain their tone, the surface appears firmer and more defined something that becomes especially important when volume is lost through GLP-1-induced weight loss