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However, although these activated progenitors produce mature OLGs in the cuprizone model, the process fails in EAE, suggesting that inflammation (in EAE) may lead to an overactivation of GPR17, thereby preventing the terminal differentiation of OPCs (Coppolino et al., 2018)

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Cell Stem Cell 16 , 113114 (2015)

In a laboratory setting, researchers investigated how a substance called delta sleep-inducing peptide (DSIP) affects the development of different cell types in the pituitary gland

Professor Alexander Borbly of the University of Zrich stated that DSIP turned out to be a flop as a sleep substance and any interest was lost