This notion is in keeping with the functional role of the glutamate-glutamine cycle and it fits with the model proposed by Hertz and Schousboe (59) based on analysis of kinetic data for glutamate uptake into cultured neurons and astrocytes
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Furthermore, its anti-inflammatory properties help protect tissues such as hepatocytes and gastrointestinal mucosa, mitigating the impact of inflammation on multiple organ systems and preventing multi-system damage from hindering the recovery process
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Common adverse effects reported with Ozempic include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the injection site Hypoglycaemia : especially when used in combination with insulin or sulfonylureas (doses of these medications may need reduction to minimise this risk) [3] [14] More serious but less common risks include: Pancreatitis : patients should be advised to seek immediate medical attention if they experience severe, persistent abdominal pain [22] [23] Gallbladder disease : including cholelithiasis and cholecystitis Diabetic retinopathy complications : particularly in patients with pre-existing retinopathy Acute kidney injury : risk increases with dehydration from severe gastrointestinal side effects Thyroid C-cell tumours : observed in rodent studies, though the relevance to humans remains uncertain [3] [14] Ozempic should not be used during pregnancy and should be discontinued if pregnancy occurs
