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Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide : STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide : SUMMIT (risk reduction in HFpEF outcomes
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GLP-1 drugs improve outcomes in Type 1 Diabetes Source: Bartelt, et al Epic Research Network March 25, 2025
Weeks 5 through 8: optimization phase Increase to 20 to 22.5 units daily (4.0 to 4.5mg total)
Researchers note that the consistency of effects across multiple substances and outcomes provides a strong rationale for dedicated clinical trials
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