select trial semaglutide nejm Updates in Medicine | 🩺 Oral Cuts CV Risk in High-Risk T2DM – SOUL (NEJM, Mar 2025) 🔗 Original article link in bio 📌 Key Highlights: 🔹 🚨 Oral Semaglutide 25 mg

Some loose skin will likely remain after significant weight loss

It really works against all major substances, and it works uniformly, not because it acts against alcohol or opioids or nicotine specifically, but because it is likely acting against the craving itself

What NOT to expect in the first 3 nights: Sedation (DSIP is not a sedative a drugged or groggy feeling is a signal to check the dose) Complete resolution of chronic insomnia (sleep architecture remodeling takes longer) Stress or cortisol changes (HPA axis modulation requires sustained dosing) Administration timing: Community protocols describe subcutaneous DSIP 30-60 minutes before the intended sleep time

This article breaks down what this peptide combination does, how it works, and what potential benefits its commonly associated with

Consistent with this, Bbs5 / mice displayed a decrease in total eWAT CD4 + T cells compared with WT controls (Figure 3I)