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This interaction promotes insulin secretion and inhibits glucagon release, contributing to reduction of glucose in blood.4 Beyond the pancreas, GLP-1 receptors are also expressed in various organs, including the brain, heart, gastrointestinal tract, lungs, liver, kidneys, adipose tissue, and skeletal muscle, contributing to its diverse physiological roles
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This process is mediated by pro-inflammatory cytokines like IL-1 and TNF, and Th1 and Th17 mediators including IFN and IL-17 [157]
For Pycnogenol constituents and metabolites, interactions with some specific structures, such as matrix proteins (21), erythrocyte membranes (22) and human albumin (23) were characterized in vitro
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