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These solutions collectively provide a method to enhance treatment efficacy while reducing systemic toxicity
The Proline-rich domain and RRM motifs of SFPQ are central for R-loop suppression To dissect the molecular basis of the SFPQDAXX interaction, we transiently expressed full-length HA-tagged DAXX together with a panel of myc-tagged SFPQ deletion mutants lacking defined protein domains, followed by co-immunoprecipitation assays (Fig
Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity
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