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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

Some patients prefer evening dosing because they can sleep through early nausea if it occurs

instead, use descriptive words and note how the pain interferes with specific daily activities, such as the ability to wear shoes or sleep with blankets

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3,4 People with serious mental illness, including schizophrenia, have a median 10-year shorter life expectancy than the general population