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The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)

Finally, we assessed the intestinal permeability of the mice, showing that SPT 2 KO intestinal flora increased intestinal permeability in recipient mice (p = 0.0309)

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