GSH (-L-glutamyl-L-cysteinylglycine) is an endogenous tripeptide found mainly in liver tissues, which are the main tissues involved in its biosynthesis
Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-l-cysteine
SAG : Animal studies show oral SAG (30 mg/kg for 8 weeks) significantly restores liver GSH, reduces GSSG (oxidized glutathione), and lowers lipid peroxidation in CCl-induced liver injury
Notably, a sublethal dose of the ferroptosis inducer erastin can inhibit, rather than promote, the lipid peroxidation induced by brefeldin A, which involves the sulfur transfer pathway and partially restores the balance of the Golgi apparatus (Alborzinia et al
JNK signalling contributes to DR5 expression and TRAIL sensitization The production of ROS can induce multiple pro-apoptotic pathways, including the JNK signalling pathway [35]