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In patients with T2DM, where islet neogenesis and -cell replication are normal, increased apoptosis is the main cause of the decrease in their -cell numbers, so preventing -cell apoptosis may become an effective means of treating T2DM (Butler et al., 2003)

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doi:10.1172/JCI59755 [PMC Full Text] [PubMed] [Crosslink] 59

The 2005 Bissett, Oblong, and Berge follow-up in Dermatologic Surgery added cutometric elasticity improvements to the measured outcomes [14]