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GSK3 phosphorylates several MAPs preventing their ability to bind to microtubules, including APC and CLASPs that stabilize microtubules at the cell cortex [55]

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GLP-1, or glucagon-like peptide-1, is a type of incretin hormone that plays a crucial role in glucose metabolism

Lilly is following this with retatrutide, a triple agonist, which has completed phase 2 trials for treating obesity and cardiovascular disease