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Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
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The downside is cost, as brand-name medications without insurance are extremely expensive, and many doctors do not work with compounding pharmacies
While many of these platforms show promise in preclinical and early clinical studies, critical translational barriers remain
renal impairment may require monitoring The one-week half-life of both components enables true once-weekly dosing while maintaining relatively stable plasma concentrations throughout the dosing interval, contributing to consistent therapeutic effects and potentially improved tolerability compared to shorter-acting agents
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