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The first published tirzepatide injection site reaction case involved a patient who had tolerated dulaglutide for years without reactions, then developed a severe reaction covering the entire lower abdomen after switching to tirzepatide

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Similarly, insurers like Health New England are ending coverage for GLP1 weightloss drugs (Saxenda, Wegovy, Zepbound) for most commercial members as of January 1, 2026, unless their employer buys an optional rider