The above findings underscore the potential of GLP-1R agonists as efficacious and safe drugs with pleiotropic activities on cardiovascular system that are independent of their glycemic control effects emphasizing cardiovascular outcomes as one of the primary goals in the management of type 2 diabetes
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Intravenous infusion of GLP-1 for 48 h in healthy human subjects increased muscle sympathetic nerve activity but had no effect on BP, norepinephrine plasma concentration, or the sympathetic/parasympathetic balance as estimated by the HR variability, suggesting that the increase in sympathetic drive is at least partially compensated by an increase in the parasympathetic activity [53]
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The potential advent of an effective tau-directed disease-targeted therapies (DTTs) for AD may increase the volume of patients presenting earlier in the disease continuum, and increase complexity in workflow, infrastructure, treatment decision-making, treatment administration and monitoring, and patient tracking