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Importantly, the ECD of GLP-1R undergoes a remarkable orientation change from the closed TMD-interacting conformation to the extended active conformation during peptide binding and activation

The problem is that patients don't know the difference, and they'll often be looking for the most accessible route to get to the medication that they want

GLP-1 receptor agonists carry a boxed warning regarding thyroid C-cell tumors, based on rodent studies showing increased incidence of medullary thyroid carcinoma (MTC) at high doses