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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females
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In eukaryotes, GSTs are divided according to their cellular localization into at least three major families of proteins, namely cytosolic GSTs, mitochondrial GSTs and microsomal GSTs 1,2,6
Current treatments, including laparoscopic excision, hormonal therapy and non-steroidal anti-inflammatory drugs, provide relief but are not curative 1,5,7,12
The practical implications of this distinction are significant
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