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After a 4-week screening period, participants were randomly assigned, 1:1:1:1:1, to once-weekly 2.5 mg, 5 mg, 10 mg or 15 mg VK2735 or placebo for 13 weeks

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Furthermore, as antioxidant rescue experiments were not performed in this study, the observed ROS accumulation remains an associated phenomenon rather than a proven causal mediator of cell death