With that said, their rapid rise in use has prompted increased scrutiny, and their status is an area to monitor as scientific understanding and usage patterns continue to evolve.
It is taken up intact by chylomicrons in the gut
When something purports to "change everything", I'm skeptical
Efficacy is not everything, access is The medical advances here are real and profound but Dr Kovil reminded, The same medicine can mean very different things to your wallet, depending on where you live. Clinical breakthroughs only translate into population health gains when systems including insurers, governments, manufacturers and regulators, make access practical and sustainable
A prespecified analysis of the SELECT trial examined the relationship between changes in adiposity measures (body weight and waist circumference) and cardiovascular outcomes among 17,604 patients with obesity or overweight and established cardiovascular disease but without diabetes.[1] The analysis revealed that cardiovascular outcomes were similar among semaglutide-treated patients who did or did not lose at least 5% of their baseline body weight, and that semaglutide consistently reduced major adverse cardiovascular events across the full spectrum of baseline body mass index values