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Furthermore, chronic GIP-receptor agonism can lead to desensitization and eventual loss of GIP receptor activity, which then mimics antagonism
A new Aon study of 50 million covered lives found that after year one, medical spend growth for GLP-1 users fell to half that of peers, and hospitalizations for major cardiovascular events dropped 44% within two years
Zhang J, Pavlova NN, Thompson CB
The rate of dropout in studies of oral semaglutide has been significant, approximately 25% in recent trials, reflecting tolerability concerns, mainly due to nausea (source)
They also have dozens of benefits and few rare side-effects
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