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Notably, vitamin B12 plays a pivotal role in the health and maintenance of nerve cells, the formation of red blood cells, and the intricate process of DNA synthesis

Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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[] This lipid storage bias is further exacerbated by impaired fatty acid oxidation in obese adipocytes