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These findings have fundamentally reshaped the treatment paradigms for both obesity and T2D

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Recommend some remedies for clients who are having GI side effects, but let them know that the side effects vary and likely will be transient

This is exemplified by experimental models showing that selective ablation or stimulation of Agouti-related peptide (AgRP)/NPY/GABA neurons in the basomedial hypothalamus leads to either starvation or hyperphagia with subsequent obesity, respectively (114, 115)

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